| Toxicological significance of dihydrodiol metabolites. | |
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MedLine Citation:
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PMID: 6298445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dihydrodiols are often found as the major organic-extractable metabolites of various olefinic or aromatic xenobiotics in many biological samples. Studies on the chemistry of dihydrodiol metabolites have provided insight into the pharmacokinetic behavior and the mode of action of the parent compound. The toxicology of dihydrodiol is more complex than what can be deduced solely on the basis of diminished bioavailability of the epoxide precursor, and the increased hydrophilicity associated with the dihydrodiol moiety. Dihydrodiols can be intrinsically toxic and may even represent metabolically activated species. Some of the dihydrodiol metabolites may still retain sufficient lipophilic character to serve again as substrates for microsomal oxygenases. Because of the tremendous chemical and biological diversity that existed among the various dihydrodiols, more mechanistic studies are needed to examine the toxicological properties of these compounds. It may be premature to conclude dihydrodiol formation as purely a detoxification route for xenobioties. |
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Authors:
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M T Hsia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of toxicology. Clinical toxicology Volume: 19 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 737-58 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1 Aflatoxins / metabolism, toxicity Alcohols / metabolism*, toxicity Aldrin / analogs & derivatives, metabolism, toxicity Animals Benz(a)Anthracenes / metabolism, toxicity Benzo(a)pyrene Benzopyrans / metabolism, toxicity Benzopyrenes / metabolism, toxicity Chemical Phenomena Chemistry Cricetinae Environmental Pollutants / analysis Insecticides / metabolism, toxicity Mutagenicity Tests Pesticide Residues Rats Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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181532//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Alcohols; 0/Benz(a)Anthracenes; 0/Benzopyrans; 0/Benzopyrenes; 0/Environmental Pollutants; 0/Insecticides; 0/Pesticide Residues; 1162-65-8/Aflatoxin B1; 309-00-2/Aldrin; 3106-29-4/aldrin-transdiol; 50-32-8/Benzo(a)pyrene; 644-06-4/precocene II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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