Document Detail


Toxicological significance of dihydrodiol metabolites.
MedLine Citation:
PMID:  6298445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dihydrodiols are often found as the major organic-extractable metabolites of various olefinic or aromatic xenobiotics in many biological samples. Studies on the chemistry of dihydrodiol metabolites have provided insight into the pharmacokinetic behavior and the mode of action of the parent compound. The toxicology of dihydrodiol is more complex than what can be deduced solely on the basis of diminished bioavailability of the epoxide precursor, and the increased hydrophilicity associated with the dihydrodiol moiety. Dihydrodiols can be intrinsically toxic and may even represent metabolically activated species. Some of the dihydrodiol metabolites may still retain sufficient lipophilic character to serve again as substrates for microsomal oxygenases. Because of the tremendous chemical and biological diversity that existed among the various dihydrodiols, more mechanistic studies are needed to examine the toxicological properties of these compounds. It may be premature to conclude dihydrodiol formation as purely a detoxification route for xenobioties.
Authors:
M T Hsia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  19     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-58     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1
Aflatoxins / metabolism,  toxicity
Alcohols / metabolism*,  toxicity
Aldrin / analogs & derivatives,  metabolism,  toxicity
Animals
Benz(a)Anthracenes / metabolism,  toxicity
Benzo(a)pyrene
Benzopyrans / metabolism,  toxicity
Benzopyrenes / metabolism,  toxicity
Chemical Phenomena
Chemistry
Cricetinae
Environmental Pollutants / analysis
Insecticides / metabolism,  toxicity
Mutagenicity Tests
Pesticide Residues
Rats
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
181532//PHS HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Alcohols; 0/Benz(a)Anthracenes; 0/Benzopyrans; 0/Benzopyrenes; 0/Environmental Pollutants; 0/Insecticides; 0/Pesticide Residues; 1162-65-8/Aflatoxin B1; 309-00-2/Aldrin; 3106-29-4/aldrin-transdiol; 50-32-8/Benzo(a)pyrene; 644-06-4/precocene II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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