Document Detail


Toxicological properties of metaflumizone.
MedLine Citation:
PMID:  17933467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metaflumizone is a new insecticide developed for crop protection and urban pest control by BASF. Its mammalian toxicological profile was assessed by conducting multiple toxicity studies in the rat, mouse, and dog, covering all relevant endpoints. Metaflumizone is characterized by very low acute toxicity, is not irritating to the eye or the skin and does not possess a potential to induce skin sensitization. The substance also shows relatively low toxicity following subchronic oral or dermal exposure to mammals. In addition, metaflumizone demonstrates low toxicological potential following chronic oral exposure to rats, mice, and dogs. Overall, the lowest no observed adverse effect level (NOAEL) is 12mg/(kgday) from the 1-year chronic dog study. In a battery of in vitro and in vivo mutagenicity assays, the weight-of-the-evidence indicates a lack of potential genotoxicity for metaflumizone. Furthermore, the compound demonstrated a lack of potential oncogenicity in long-term toxicity studies in rats and mice. Results from the rat multi-generation reproductive toxicity study as well as the rat and rabbit developmental toxicity studies indicate that metaflumizone is not selectively toxic to the offspring or fetus, as compared to the parents. Also, metaflumizone is not teratogenic in the rat or rabbit. Lastly, no neurotoxicity could be detected in acute and subchronic neurotoxicity studies in rats.
Authors:
K Hempel; F G Hess; C Bögi; E Fabian; J Hellwig; I Fegert
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Publication Detail:
Type:  Journal Article     Date:  2007-10-22
Journal Detail:
Title:  Veterinary parasitology     Volume:  150     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  190-5     Citation Subset:  IM    
Affiliation:
BASF Aktiengesellschaft, GUP/CP and GV/T-Z470, D-67056 Ludwigshafen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Female
Fetal Development / drug effects*
Guinea Pigs
Male
Mice
Pregnancy
Rabbits
Rats
Rats, Sprague-Dawley
Rats, Wistar
Reproduction / drug effects*
Semicarbazones / pharmacokinetics,  toxicity*
Skin / drug effects
Toxicity Tests
Chemical
Reg. No./Substance:
0/Semicarbazones; 0/metaflumizone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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