Document Detail


Toxicological properties of citrinin.
MedLine Citation:
PMID:  20061247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Citrinin (CTN) is a nephrotoxic mycotoxin produced by several fungal strains belonging to the genera Penicillium, Aspergillus, and Monascus. It contaminates various commodities of plant origin, cereals in particular, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A (OTA). These two mycotoxins are believed to be involved in the aetiology of endemic nephropathy. In addition to nephrotoxicity, CTN is also embryocidal and fetotoxic. The genotoxic properties of CTN have been demonstrated with the micronuleus test (MN), but not with single-cell gel electrophoresis. The mechanism of CTN toxicity is not fully understood, especially not whether CTN toxicity and genotoxicity are the consequence of oxidative stress or of increased permeability of mitochondrial membranes. CTN requires complex cellular biotransformation to exert mutagenicity.Compared with other mycotoxins, CTN contamination of food and feed is rather scarce. However, it is reasonable to believe that humans are much more frequently exposed to CTN than generally accepted, because it is produced by the same moulds as OTA, which is a common contaminant of human food all over the world.At present, there are no specific regulations either in Croatia or in the European Union concerning CTN in any kind of commodity.
Authors:
Dubravka Flajs; Maja Peraica
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  60     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  457-64     Citation Subset:  IM    
Affiliation:
Institute for Medical Research and Occupational Health, Zagreb, Croatia. dfl ajs@imi.hr
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / toxicity
Citrinin / analysis,  toxicity*
Food Contamination / analysis
Humans
Kidney / drug effects
Mutagens / toxicity
Teratogens / toxicity*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mutagens; 0/Teratogens; 518-75-2/Citrinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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