Document Detail


Toxicological and pharmacological investigations of pinazepam (7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one): a new psychotherapeutic agent.
MedLine Citation:
PMID:  240369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacological and toxicological properties of 7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one (pinazepam) were investigated and compared with those of diazepam. In mouse and rat acute toxicity, in rat motor coordination and in rat metrazol convulsion tests pinazepam was compared with oxazepam too. Pinazepam, which is characterized by the presence of a propargylic side chain, showed a lower toxicity, hypnotic activity and muscular-relaxant activity than diazepam. Pinazepam and diazepam showed, however, similar activity in reducing aggressive behaviour in mice, stimulating the exploratory behaviour in rats and in potentiating hexobarbital narcosis. No clear-cut differences were observed in the anticonvulsant properties of the two drugs when tested against metrazol, strychnine and electroshock induced seizures. Pinazepam differs from diazepam for its longer duration of action. The main metabolic product found in the urine of rats and dogs treated with pinazepam was oxazepam.
Authors:
F Scrollini; S Caliari; A Romano; P Torchio
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  25     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-25     Completed Date:  1975-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  934-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology
Aggression / drug effects
Analgesia
Animals
Anti-Anxiety Agents / metabolism,  pharmacology*,  toxicity
Blood Pressure / drug effects
Cats
Diazepam / pharmacology
Dogs
Exploratory Behavior / drug effects
Female
Heart Rate / drug effects
Humans
Male
Mice
Motor Activity / drug effects
Motor Skills / drug effects
Muscle Tonus / drug effects
Oxazepam / pharmacology
Pregnancy
Rabbits
Rats
Reflex / drug effects
Seizures / prevention & control
Sleep / drug effects
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 439-14-5/Diazepam; 604-75-1/Oxazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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