| Toxicological evaluation and bioavailability of (14)C-fenitrothion bound residues on soybeans towards experimental animals. | |
| | |
MedLine Citation:
|
PMID: 18639607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Under local practice of Egyptian conditions, the application of (14)C-fenitrothion on soybeans at a dose of 10mg insecticide/kg grains, led to the formation of 21% of (14)C-bound residues (non-extractable) after 24 weeks of storage. The external residues were 20% and the internal extracts were 55% of the applied dose. Feeding studies on rats revealed that bound residues were bioavailable. After feeding rats for three days with bound (14)C-fenitrothion residues, the main portion of radioactivity was eliminated via expired air (42%), urine (20%) and feces (11.5%). About 15% of the administered radioactivity was distributed among various organs as, liver, kidney, lung, fat, intestine, blood, heart, and brain. Toxicity of bound residues of (14)C-fenitrothion in stored soybeans was studied in mice through feeding experiments for three months at a concentration of 1.9 mg/kg. The maximum inhibition in plasma and erythrocyte cholinesterase activity was observed 22.5%, 18.9% and 8.6%, 9% after one and seven days, respectively. The obtained results showed a slight significant elevation after three months in the activity of liver enzymes alanine amino transferase, aspartate amino transferase and alkaline phosphatase. A moderate increase in blood urea nitrogen and creatinine concentration was observed in the treated groups at the end of the experimental period. The detected levels of albumin and total protein showed no significant compared to the control values, of controlled animals, after three months. |
| | |
Authors:
|
M Farghaly; S El-Maghraby |
Related Documents
:
|
11043607 - Distribution of [14c]suramin in tissues of male rats following a single intravenous dose. 6894697 - Absorption, distribution and excretion of 14c-pirenzepine in rats. accumulation charact... 11701217 - Absorption, distribution, metabolism and excretion of daily oral doses of [14c]methyl p... 109197 - Disposition of 5-methyltetrahydrohomofolate in mice, dogs, and monkeys. 6307587 - Naloxone in septic shock. 19295397 - Median effective infusion dose (ed50) of alfentanil for monitored anesthesia care of pe... |
Publication Detail:
|
Type: Journal Article Date: 2008-06-29 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 46 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-04 Completed Date: 2008-11-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
|
Languages: eng Pagination: 3111-5 Citation Subset: IM |
Affiliation:
|
Department of Applied Organic Chemistry, National Research Centre, Dokki, Giza, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholinesterase
/
metabolism Animals Biological Availability Feces / chemistry Fenitrothion / pharmacokinetics*, toxicity* Insecticides / pharmacokinetics*, toxicity* Kidney / drug effects, enzymology Liver / drug effects, enzymology Male Pesticide Residues / pharmacokinetics*, toxicity* Rats Rats, Sprague-Dawley Seeds / chemistry Soybeans / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Insecticides; 0/Pesticide Residues; 122-14-5/Fenitrothion; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Piperine, the potential functional food for mood and cognitive disorders.
Next Document: HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR).