| Toxicological evaluation of RGTA OTR4120, a heparan sulfate mimetic. | |
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MedLine Citation:
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PMID: 20452387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparan sulfate mimetic polymers promotes tissue repair when injected locally in doses of 1-2mg/kg by various routes. These biopolymers, have been extensively studied for their diverse biological activities. However, there is no detailed report investigating the toxicity of OTR4120. In this study, the acute and subchronic (30 days) toxicity of varying levels of OTR4120 was investigated in mice after intraperitoneal administration. The results showed that no significant toxicological changes were observed when 50mg/kg body weight per day OTR4120 was administered to mice. But when the dose was increased to 60 and 70 mg/kg body weight per day, the clotting time was significantly prolonged. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were reduced female and male at dose 70 mg/kg body weight per day. These blood biochemistry data suggest that OTR4120 have a hepatoprotective effect. Based on these results, it can be concluded that the no adverse effect level of OTR4120 is 50 mg/kg body weight per day. |
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Authors:
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Said Charef; Michel Tulliez; Liliane Esmilaire; José Courty; Dulce Papy-Garcia |
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Publication Detail:
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Type: Journal Article Date: 2010-05-07 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1965-8 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratoire CRRET/CNRS UMR 7149, Université Paris 12 val de Marne, PRES Paris Est, 61, Avenue du Général de Gaulle 94010, Créteil Cedex, France. charef@univ-paris12.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomimetics Blood Cell Count Blood Coagulation / drug effects Body Weight / drug effects Dose-Response Relationship, Drug Enzymes / blood Female Glycosaminoglycans / chemical synthesis, chemistry, toxicity* Heparitin Sulfate / chemistry* Injections, Intraperitoneal Male Mice Organ Size / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Enzymes; 0/Glycosaminoglycans; 0/OTR4120; 9050-30-0/Heparitin Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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