| Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. | |
| | |
MedLine Citation:
|
PMID: 21744743 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: Recent rapid advances in nanotechnology raise concerns about development, production route, and diffusion in industrial and consumer products of titanium dioxide nanoparticles (TiO2-NPs). In fact, compared to recent increase in applications of this nanomaterial, the health effects of human exposure have not been systematically investigated. The aim of this review was to provide a comprehensive overview on the current knowledge regarding the effects of TiO2-NPs on mammalian cells. EVIDENCE AND INFORMATION SOURCES: This review is based on an analysis of the current literature on this topic. STATE OF THE ART: Fine TiO2 particles have been considered as safe and to pose little risk to humans, suggesting that exposure to this material is relatively harmless. However, available data in the literature showed that TiO2-NPs can cause several adverse effects on mammalian cells such as increase of reactive oxygen species (ROS) production and cytokines levels, reduction of cell viability and proliferation, induction of apoptosis and genotoxicity. PERSPECTIVES AND CONCLUSIONS: Additional research is needed to obtain up-to-date knowledge on health effects of TiO2-NPs and to avoid any potential risk correlated to their exposure. Consequently, future studies need to: (1) use an homogeneous and rigorous exposure classification to clarify how the physicochemical properties of TiO2-NPs correlate with their toxicological effects; (2) assess the potential adverse effects of low level exposures to TiO2-NPs, as most of the information currently available originates from studies in which exposure levels were excessively and unrealistically high; (3) identify the possible roles of TiO2-NPs in genotoxicity and carcinogenicity (4) carry out epidemiologic studies of exposed workers to provide an assessment of possible risks correlated to the occupational exposure to TiO2-NPs. |
| | |
Authors:
|
I Iavicoli; V Leso; L Fontana; A Bergamaschi |
Related Documents
:
|
21187343 - The regulation of autophagy - unanswered questions. 19869833 - Studies on inflammation : v. the mechanism of fixation by the inflammatory reaction. 23639963 - Innate immunity functional genes polymorphisms and gout susceptibility. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European review for medical and pharmacological sciences Volume: 15 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-07-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 481-508 Citation Subset: IM |
Affiliation:
|
Institute of Occupational Medicine, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. iavicoli.ivo@rm.unicatt.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New trends in nutritional status assessment of cancer patients.
Next Document: Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.