Document Detail


Toxicological comparisons of three styles of a commercial U.S. cigarette (Marlboro with the 1R4F reference cigarette.
MedLine Citation:
PMID:  18464057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxicological comparisons were made of three commercial cigarettes, namely Marlboro full flavor, Marlboro Lights, and Marlboro Ultra Lights, with the 1R4F reference cigarette. The main comparison was a 90-d inhalation study with mainstream smoke at 150 mg total particulate matter per cubic meter, in Sprague-Dawley rats using 6 h/d and 7 d/w exposures. The principal endpoint was histopathology of the respiratory tract, along with examinations of free lung cell counts after broncho-alveolar lavage. Additional studies on mainstream smoke included Salmonella mutagenicity, cytotoxicity of particulate and gas/vapor phases, and analytical chemistry. The exposures produced effectively the same responses in each of the four groups, and the histopathology results in the commercial cigarette groups were also effectively the same. The 1R4F was also tested at 75 and 200 mg/m(3), and most of the histopathology results obtained here showed dose-response relationships. The free lung cell responses were similar in the 1R4F/commercial cigarette comparison, and there were dose-related changes in the 1R4F groups, most notably for neutrophils. Most of the changes produced in the 90-d of exposure were resolved in a 42-d post-inhalation period. Responses in the in vitro and analytical assays for the four cigarettes were in general similar, when data were expressed either per mg TPM or per mg tar yield. There were judged to be no toxicologically meaningful differences between the profiles evaluated at similar smoke concentrations for the three commercial cigarettes and for the 1R4F using these assays.
Authors:
George J Patskan; Kenneth F Podraza; Kris Meurrens; Christopher R E Coggins; Bärbel Friedrichs; Birgit Gerstenberg; Willy Gomm; Peter Schnell; Regina Stabbert; Detlef Veltel; Susanne Weber; Piter Terpstra
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  20     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-721     Citation Subset:  IM    
Affiliation:
Philip Morris USA, Inc., Richmond, Virginia, USA. george. j.patskan@pmusa.com
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MeSH Terms
Descriptor/Qualifier:
Animals
BALB 3T3 Cells
Bronchoalveolar Lavage Fluid / cytology
Carboxyhemoglobin / analysis
Cell Survival / drug effects
Female
Male
Mice
Mutagens / toxicity
Particulate Matter / analysis,  toxicity
Rats
Rats, Sprague-Dawley
Respiratory Function Tests
Respiratory System / drug effects*,  pathology
Salmonella / drug effects*,  genetics
Smoke / adverse effects*,  analysis
Tobacco / toxicity*
Chemical
Reg. No./Substance:
0/Mutagens; 0/Particulate Matter; 0/Smoke; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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