| Toxicological assessment of liquorice: biliary excretion in rats. | |
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MedLine Citation:
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PMID: 9299212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycyrrhizin (G) and its aglycone, glycyrrhetic acid (GA) have been prescribed for several therapeutic purposes. However, side effects have pointed out the problem of the toxicity of G. On the contrary, it was recently shown that the pure aqueous liquorice extract (LE), which also contains G, produces reduced adverse effects in rat and human, as compared to pure G, this is likely be related to differences in G bioavailability and the resulting pharmacokinetics of G and GA. Using a sensitive HPLC procedure for the determination of G and GA in rat bile, pharmacokinetics of G and GA in bile have been determined. The results of the analysis showed significantly lower concentrations of G in bile samples from rats treated with LE compared to pure G. Furthermore, LE presented a significant choleretic effect after both oral and i.v. administration, which increases the excretion rate of G. In case of GA, all the concentrations were very low, often below the detection limit. The results prompted us to assess the risk associated with liquorice intake and to determine the daily amount of pure liquorice root extract that can be safely consumed. |
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Authors:
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G Cantelli-Forti; M A Raggi; F Bugamelli; F Maffei; A Villari; N M Trieff |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 35 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-11-24 Completed Date: 1997-11-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 463-70 Citation Subset: IM |
Affiliation:
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Dipartimento di Farmacologia, Università di Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, toxicity Bile / metabolism* Biological Availability Calibration Chromatography, High Pressure Liquid Glycyrrhiza / metabolism*, toxicity* Glycyrrhizic Acid / administration & dosage, pharmacokinetics, toxicity Injections, Intravenous Intestinal Absorption Male Plant Extracts / administration & dosage, metabolism, toxicity Plants, Medicinal* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Plant Extracts; 1405-86-3/Glycyrrhizic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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