| Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats. | |
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MedLine Citation:
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PMID: 19197915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. |
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Authors:
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Edvaldo Rodrigues de Almeida; Flávia Raquel Santos Lucena; Camilla Vila Nova Soares Silva; Wilson da Silva Costa-Junior; Jouse Bezerra Cavalcanti; Gerald Bosco Lindoso Couto; Luiz Lúcio Soares da Silva; Diógenes Luís da Mota; Alex Benício da Silveira; Samuel Daniel de Sousa Filho; Aldo Cezar Passilongo da Silva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-27 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1276-80 Citation Subset: IM |
Affiliation:
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Laboratory of Evaluation of Psychobioactive Drugs and its Toxicology, Federal University of Pernambuco, 50670-901 Recife PE, Brazil. Edvaldo.ra@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood Animals Female Leukocytes / pathology Male Naphthoquinones / toxicity* Pregnancy Rats Rats, Wistar Spleen / pathology Teratogens / toxicity* Toxicity Tests, Chronic Transaminases / blood gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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0/Naphthoquinones; 0/Teratogens; 4707-32-8/beta-lapachone; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.-/Transaminases; EC 3.1.3.1/Alkaline Phosphatase |
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