Document Detail

Toxicological aspects of topical silver pharmaceuticals.
MedLine Citation:
PMID:  8726163     Owner:  NLM     Status:  MEDLINE    
Silver is generally considered to present a relatively low toxic threat to humans because unintentional exposure to large doses of the noble metal is quite rare. However, as the intentional utilization of silver in pharmaceutical preparations and devices increases, subtle toxic effects of silver may be predictable and expected. The present review examines the scientific literature, primarily covering the past 10 years, dealing with reports describing various types of silver toxicity. These reports consist of both in vitro and in vivo data dealing with immunological, mesenchymal, neural, and parenchymal cell types. Particular emphasis is given to (1) the use of silver in topical antimicrobial preparations as toxicity relates to absorption through dermal wounds into the systemic circulation and possible effects on delayed wound healing, (2) possible local silver toxicity via iontophoretic devices, (3) current theories relating to the toxicological mechanism of action of silver.
M A Hollinger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  26     ISSN:  1040-8444     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis 95616, USA.
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MeSH Terms
Administration, Topical
Anti-Infective Agents, Local / administration & dosage,  therapeutic use,  toxicity*
Burns / drug therapy,  metabolism
Drug Combinations
Electrodes / adverse effects
Immunity, Cellular / drug effects
Silver / administration & dosage,  therapeutic use,  toxicity*
Skin Absorption
Sulfadiazine / adverse effects
Wound Healing / drug effects*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Drug Combinations; 68-35-9/Sulfadiazine; 7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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