| Toxicologic studies in a fatal overdose of 2,4-D, MCPP, and chlorpyrifos. | |
| | |
MedLine Citation:
|
PMID: 6193335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A death due to ingestion of 2,4-dichlorophenoxyacetic acid (2,4-D), 2-(2-methyl-4-chlorophenoxy) propionic acid (MCPP), and phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl)ester (chlorpyrifos) is reported. The clinical course, dose ingested, and plasma levels of the chemicals were compatible with previous fatalities due to the chlorophenoxyacetic acids. Chlorpyrifos concentrations and tissue cholinesterase and in esterase inhibitions indicated the presence of the organophosphate and its biochemical effect, but few cholinergic signs were observed clinically. Lymphocytic neurotoxic esterase activity was decreased for a limited period of time after ingestion. Postmortem nervous tissue neurotoxic esterase was also decreased. This association has not been demonstrated before in man. HPLC and GC/NPD methods for measuring chlorophenoxy acetic acids and chlorpyrifos, respectively, are presented. |
| | |
Authors:
|
J Osterloh; M Lotti; S M Pond |
Related Documents
:
|
10690565 - Essential fatty acid metabolism in the micropremie. 6930315 - In vivo utilization of substrate by human sarcoma-bearing limbs. 11709075 - Uncoupling protein 3 and fatty acid metabolism. 8816765 - Intracellular ph in adipocytes: effects of free fatty acid diffusion across the plasma ... 2961415 - Increased quinolinic acid metabolism following neuronal degeneration in the rat hippoca... 6400835 - Interaction of nucleic acids with lipid membranes. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of analytical toxicology Volume: 7 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 1983 May-Jun |
Date Detail:
|
Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 125-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
2,4-Dichlorophenoxyacetic Acid
/
analysis,
poisoning* 2-Methyl-4-chlorophenoxyacetic Acid / analogs & derivatives, analysis, poisoning* Adult Chlorpyrifos / analysis, poisoning* Chromatography, Gas Chromatography, High Pressure Liquid Esterases / analysis Glycolates / poisoning* Herbicides / analysis, poisoning* Humans Male |
| Chemical | |
Reg. No./Substance:
|
0/Glycolates; 0/Herbicides; 2921-88-2/Chlorpyrifos; 93-65-2/mecoprop; 94-74-6/2-Methyl-4-chlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid; EC 3.1.-/Esterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methods in laboratory investigation. Application of the indirect enzyme-linked immunosorbent assay m...
Next Document: Hormonal and cholinergic effects on amylase and lysosomal enzyme activities in pancreatic tissue and...