| Toxicokinetics of three polychlorinated biphenyl technical mixtures in rainbow trout (Oncorhynchus mykiss). | |
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MedLine Citation:
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PMID: 15230325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulation and depuration parameters of polychlorinated biphenyls (PCBs) in fish have been reported only for a few congeners. As well, there is little information on the ability of fish to biotransform PCBs. To address these issues, juvenile rainbow trout (Oncorhynchus mykiss) were exposed to dietary concentrations of three Aroclor mixtures (1248, 1254, 1260) in food for 30 d followed by an additional 160 d of nonspiked food at 8 degrees C. Accumulation, depuration, and potential biotransformation of 92 PCB congeners were assessed. Half-lives (t1/2) of PCB congeners ranged from 79 to 182 d, assimilation efficiencies ranged from 40 to 50% and biomagnification factors (BMF) ranged from 2.9 to 6.9. No evidence of significant biotransformation of any PCB congeners was found. All 92 congeners fell on the same t1/2 to Kow relationship as 16 preselected PCB congeners previously shown to persist in fish and no hydroxylated PCB metabolites (OH-PCBs) were detected in the plasma after 30 d of exposure. These findings suggest that OH-PCBs observed in feral fish may be accumulated from sources other than internal metabolism of the parent congeners, at least for juvenile fish at cool temperatures. Because t1/2s in this experiment were slower than t1/2s reported in other work, water temperature also may be an important factor in determining the t1/2s of all PCB congeners in fish. |
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Authors:
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Andrea H Buckman; Scott B Brown; Paul F Hoekstra; Keith R Solomon; Aaron T Fisk |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: 23 ISSN: 0730-7268 ISO Abbreviation: Environ. Toxicol. Chem. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-02 Completed Date: 2004-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1725-36 Citation Subset: IM |
Affiliation:
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Department of Environmental Biology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Cytochrome P-450 CYP1A1 / metabolism Diet Food Contamination* Half-Life Hydroxylation Polychlorinated Biphenyls / chemistry, pharmacokinetics*, toxicity Temperature Trout / metabolism* Water Pollutants, Chemical / pharmacokinetics*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Polychlorinated Biphenyls; 0/Water Pollutants, Chemical; EC 1.14.14.1/Cytochrome P-450 CYP1A1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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