| Toxicokinetics of tetrabromobisphenol a in humans and rats after oral administration. | |
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MedLine Citation:
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PMID: 16481339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and is suspected to be stable in the environment with possible widespread human exposures. This study reports the characterization of the toxicokinetics of TBBPA in human subjects and in rats. A single oral dose of 0.1 mg/kg TBBPA was administered to five human subjects. Rats were administered a single oral dose of 300 mg TBBPA/kg body weight. Urine and blood concentrations of TBBPA and its metabolites were determined by LC/MS-MS. TBBPA-glucuronide and TBBPA-sulfate were identified as metabolites of TBBPA in blood and urine of the human subjects and rats. In blood, TBBPA-glucuronide was detected in all human subjects, whereas TBBPA-sulfate was only present in blood from two individuals. Maximum plasma concentrations of TBBPA-glucuronide (16 nmol/l) were obtained within 4 h after administration. In two individuals where TBBPA-sulfate was present in blood, maximum concentrations were obtained at the 4-h sampling point; the concentrations rapidly declined to reach the limit of detection (LOD) after 8 h. Parent TBBPA was not present in detectable concentrations in any of the human plasma samples. TBBPA-glucuronide was slowly eliminated in urine to reach the LOD 124 h after administration. In rats, TBBPA-glucuronide and TBBPA-sulfate were also the major metabolites of TBBPA present in blood; in addition, a diglucuronide of TBBPA, a mixed glucuronide-sulfate conjugate of TBBPA, tribromobisphenol A, and the glucuronide of tribromobisphenol A were also present in low concentrations. TBBPA plasma concentrations peaked at 103 micromol/l 3 h after administration and thereafter declined with a half-life of 13 h; maximal concentrations of TBBPA-glucuronide (25 micromol/l) were also observed 3 h after administration. Peak plasma concentrations of TBBPA-sulfate (694 micromol/l) were reached within 6 h after administration. The obtained results suggest absorption of TBBPA from the gastrointestinal tract and rapid metabolism of the absorbed TBBPA by conjugation resulting in a low systemic bioavailability of TBBPA. |
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Authors:
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Ute M D Schauer; Wolfgang Völkel; Wolfgang Dekant |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-15 |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: 91 ISSN: 1096-6080 ISO Abbreviation: Toxicol. Sci. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-06-21 Revised Date: 2010-09-17 |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Affiliation:
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Department of Toxicology, University of Würzburg, 97078 Würzburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Area Under Curve Chromatography, High Pressure Liquid Flame Retardants / administration & dosage, pharmacokinetics*, toxicity* Gas Chromatography-Mass Spectrometry Humans Male Polybrominated Biphenyls / administration & dosage, blood, pharmacokinetics*, toxicity* Rats Rats, Sprague-Dawley Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Flame Retardants; 0/Polybrominated Biphenyls; 79-94-7/tetrabromobisphenol A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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