| Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon (Acipenser transmontanus). | |
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MedLine Citation:
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PMID: 15949845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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White sturgeon (Acipencer transmontanus) were exposed to 7.2 microM (1.0 ppm) 14C-labeled p-nitrophenol (PNP) in brackish water for 24 h and then allowed to depurate in clean brackish water for another 24h. Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate. |
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Authors:
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P L TenBrook; S M Kendall; R S Tjeerdema |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2005-06-08 |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 64 ISSN: 0147-6513 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-09 Completed Date: 2006-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 362-8 Citation Subset: IM |
Affiliation:
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Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA. ptenbroo@pacbell.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Fishes / metabolism* Motor Activity / drug effects Nitrophenols / analysis, pharmacokinetics*, toxicity* Toxicity Tests Water Pollutants, Chemical / analysis, pharmacokinetics*, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Nitrophenols; 0/Water Pollutants, Chemical; 100-02-7/4-nitrophenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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