Document Detail

Toxicity to topical dimethyl sulfoxide in a pediatric patient with anthracycline extravasation.
MedLine Citation:
PMID:  15770831     Owner:  NLM     Status:  MEDLINE    
Accidental extravasation of vesicant chemotherapy may cause important tissue injuries. Nowadays, the majority of authors propose topical dimethyl sulfoxide (DMSO), with or without local cooling, as the treatment of choise efor anthracyclines extravasation. No significant toxicity has been reported when DMSO is used as topical treatment. This report describes a case of local toxicity consisting of severe pain after its use in a pediatric patient. An illustration shows the extravasation area.
M E Llinares; M Bermúdez; J L Fuster; M S Diaz; C M Gonzalez
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  22     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-09-27     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Division of Hematology Oncology, Pediatric Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage,  adverse effects
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects*
Child, Preschool
Dimethyl Sulfoxide / adverse effects*,  therapeutic use
Extravasation of Diagnostic and Therapeutic Materials / drug therapy*
Leukemia, Myelomonocytic, Acute / drug therapy
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 67-68-5/Dimethyl Sulfoxide

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