| Toxicity tests on dental filling materials. | |
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MedLine Citation:
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PMID: 6946044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rabbit muscle implantation test as described by Lawrence et al. (1972) was applied evaluate the acute non-specific toxicity of 3 amalgams and 2 composite materials, in order to test both the materials' toxicity and the suitability of the method used. The materials were implanted after different ageing times: 5 min, 1 h, 24 h and 7 days. Macroscopical as well as microscopical evaluation was performed. Biological reactions of the amalgams proved to be dependent upon the ageing time. All amalgams were strongly toxic at the 5-min and 1-h periods. By the 7-day period the high-copper two component amalgam showed a moderate reaction, the other two amalgams no or uncertain reactions. The composite materials did not show a dependency of the toxicity upon the ageing time as did the amalgams. They evoked a slight to moderate tissue reaction. The results obtained in this study are in accordance with clinical experience. We regard the rabbit muscle implantation test as a suitable method for screening the chemically initiated toxicity of solid materials. |
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Authors:
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G Schmalz; C Schmalz |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International dental journal Volume: 31 ISSN: 0020-6539 ISO Abbreviation: Int Dent J Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374714 Medline TA: Int Dent J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 185-92 Citation Subset: D; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials Composite Resins / toxicity* Dental Amalgam / toxicity* Rabbits Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Composite Resins; 8049-85-2/Dental Amalgam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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