Document Detail

Toxicity of sulphur-containing compounds to neuronal cell lines.
MedLine Citation:
PMID:  7595598     Owner:  NLM     Status:  MEDLINE    
Cysteine and its metabolites cysteine sulphinic acid (CSA) and taurine (TA) were shown to be toxic to human and rat neuronal cell lines. However, the mechanisms of action of CSA and TA appeared to be different. As MND/ALS patients have high plasma and CSF cysteine levels, they may have increased levels of neurotoxins in vivo, since cysteine was more toxic than CSA in the assay system used. Cysteic acid, homocysteic acid, BMAA and BOAA were also toxic to the cell lines used.
A R Pean; R B Parsons; R H Waring; A C Williams; D B Ramsden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  129 Suppl     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-24     Completed Date:  1995-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  107-8     Citation Subset:  IM    
School of Biochemistry, University of Birmingham, Edgbaston, UK.
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MeSH Terms
Cell Line
L-Lactate Dehydrogenase / metabolism
Neurons / drug effects*,  enzymology
Neurotoxins / toxicity*
Sulfur / toxicity*
Tumor Cells, Cultured
Reg. No./Substance:
0/Neurotoxins; 7704-34-9/Sulfur; EC Dehydrogenase

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