| Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies. | |
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MedLine Citation:
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PMID: 2276703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were fed in the diet to male F344 rats in two chronic feeding studies. In one study, feeding BHT for 76 wk at concentrations ranging from 100 to 6000 ppm produced no increase in neoplasms at any site. In a second study, feeding 12,000 ppm BHT for 110 wk had no neoplastic effect at any site, whereas feeding BHA at 12,000 ppm resulted in a small increase in squamous cell papillomas of the non-glandular squamous portion of the stomach. |
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Authors:
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G M Williams; C X Wang; M J Iatropoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 28 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-03-01 Completed Date: 1991-03-01 Revised Date: 2006-03-13 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 799-806 Citation Subset: IM |
Affiliation:
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American Health Foundation, Valhalla, NY 10595. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Butylated Hydroxyanisole / administration & dosage, toxicity* Butylated Hydroxytoluene / administration & dosage, toxicity* Diet Hyperplasia Liver / drug effects Liver Neoplasms / chemically induced* Male Neoplasms / chemically induced* Organ Size / drug effects Papilloma / chemically induced Rats Rats, Inbred F344 Stomach Neoplasms / chemically induced* |
| Chemical | |
Reg. No./Substance:
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128-37-0/Butylated Hydroxytoluene; 25013-16-5/Butylated Hydroxyanisole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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