Document Detail

Toxicity of sevoflurane in rats.
MedLine Citation:
PMID:  3605695     Owner:  NLM     Status:  MEDLINE    
Sevoflurane, an experimental potent volatile anesthetic with a low blood/gas partition coefficient, degrades in the presence of soda lime to products the toxicity of which is unknown. We tested whether toxic products were produced by the passage of sevoflurane through soda lime, and a comparison was made of the toxicity of sevoflurane passed through soda lime with the toxicity of other potent volatile anesthetics in current clinical use. Halothane, isoflurane, sevoflurane (all in 1-MAC concentrations), or no anesthetic (control) were passed through soda lime for 4 hr with 12, 14, or 100% oxygen to groups of rats with hepatic microsomal enzyme induction. Separate groups of 12-13 rats were given 1 MAC of sevoflurane that had not passed through soda lime and either 14 or 100% oxygen. Sevoflurane was no more toxic than isoflurane and both of these anesthetics were less toxic than halothane. Soda lime was not a factor in any toxicity produced. Hepatic injury with all agents varied inversely with the oxygen concentration administered during anesthesia.
D P Strum; E I Eger; B H Johnson; E P Steffey; L D Ferrell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  66     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-24     Completed Date:  1987-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-73     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthetics / toxicity*
Calcium Compounds*
Ethers / toxicity*
Halothane / toxicity
Isoflurane / toxicity
Liver / drug effects
Lung / drug effects
Methyl Ethers*
Rats, Inbred Strains
Sodium Hydroxide / pharmacology
Grant Support
P01AG03014-05/AG/NIA NIH HHS
Reg. No./Substance:
0/Anesthetics; 0/Calcium Compounds; 0/Ethers; 0/Methyl Ethers; 0/Oxides; 1310-73-2/Sodium Hydroxide; 151-67-7/Halothane; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 8006-28-8/soda lime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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