Document Detail

Toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid on freshwater macroinvertebrates (Daphnia magna and Moina macrocopa) and fish (Oryzias latipes).
MedLine Citation:
PMID:  18593212     Owner:  NLM     Status:  MEDLINE    
Because of their global distribution, persistence, and tendency to bioaccumulate, concerns about perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are growing. We determined the toxicity of PFOS and PFOA in several freshwater organisms, including two cladocerans, Daphnia magna and Moina macrocopa, and the teleost Oryzias latipes. In general, PFOS is approximately 10 times more toxic than PFOA in these organisms. In M. macrocopa, the median lethal concentration (LC50) was 17.95 mg/L for PFOS and 199.51 mg/L for PFOA. Moina macrocopa exhibited greater sensitivity than D. magna to both perfluorinated compounds in both acute and chronic exposures. In the 48-h acute toxicity test, M. macrocopa was approximately two times more sensitive than D. magna. In the 7-d chronic toxicity test, M. macrocopa showed significant reproductive changes at 0.31 mg/L for PFOS, which was approximately seven times lower than the effect concentrations observed over the 21-d exposure in D. magna. Two-generation fish toxicity tests showed that parental exposure to both compounds affected the performance of offspring. Unexposed progeny-generation (F1) fish exhibited elevated mortality and histopathological changes that were correlated with exposure in the parental generation (F0). Continuous exposure from F0 through F1 generations increased the extent of adverse effects. Considering the persistent nature of PFOS and PFOA, more research is required to determine potential consequences of long-term exposure to these compounds in aquatic ecosystems.
Kyunghee Ji; Younghee Kim; Sorin Oh; Byeongwoo Ahn; Hyunye Jo; Kyungho Choi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  27     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2159-68     Citation Subset:  IM    
School of Public Health, Seoul National University, Seoul 110-799, Korea.
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MeSH Terms
Alkanesulfonic Acids / toxicity*
Cladocera / physiology*
Daphnia / physiology*
Fluorocarbons / toxicity*
Fresh Water
Octanoic Acids / toxicity*
Oryzias / physiology*
Reproduction / drug effects
Survival Analysis
Thyroid Gland / pathology
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Fluorocarbons; 0/Octanoic Acids; 0/Water Pollutants, Chemical; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid

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