Document Detail

Toxicity of nano gamma alumina to neural stem cells.
MedLine Citation:
PMID:  22097496     Owner:  NLM     Status:  In-Process    
Nano alumina, one of the most important nanomaterials, is widely used in diverse areas. It was reported that nano alumina could cross the blood brain barrier to enter the brain. Considering aluminum accumulation in brain is closely related to many neural diseases. We studied the neural toxicity of four nano gamma-alumina samples by using neural stem cells (NSCs) C17.2 as a model. We find that the toxicity of nano gamma-alumina is pretty low, though these alumina particles are easily internalized by cells. The loss of cell viability and membrane integrity are dose-dependent and sample-dependent after alumina exposure. At concentrations lower than 100 microg/mL, no significant toxicity is observed for all alumina samples. When the concentration reaches 200 microg/mL, alumina treated cells begin to loss their activities. No culture period effect (up to 3 days) is observed. Very tiny soluble aluminum and the absorption of culture medium ingredients onto alumina particles do not affect the cell viability. Intracellular reactive oxygen species generation may contribute to the cytotoxicity of alumina particles at high concentration, but it does not induce the apoptosis of NSCs.
Erya Dong; Yanli Wang; Sheng-Tao Yang; Yuan Yuan; Haiyu Nie; Yanli Chang; Lin Wang; Yuanfang Liu; Haifang Wang
Related Documents :
18550396 - Cell cycle dependent role of hdac1 for proliferation control through modulating ribosom...
15642786 - Identification of alpha-enolase as a nuclear dna-binding protein in the zona fasciculat...
20208006 - Novel function of b cell-activating factor in the induction of il-10-producing regulato...
11684436 - The interplay between mad and myc in proliferation and differentiation.
10937346 - Human bone marrow stroma-dependent myeloma sister cell lines molp-6 and molp-7 derived ...
1267186 - Postnatal growth of the dorsal lateral geniculate nucleus of the cat.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  11     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7848-56     Citation Subset:  IM    
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preparation of ethosomes and deformable liposomes encapsulated with 5-fluorouracil and their investi...
Next Document:  Interaction between fullerenes and single-wall carbon nanotubes: the influence of fullerene size and...