Document Detail


Toxicity and mutagenicity of radiation from fluorescent lamps and a sunlamp in L5178y mouse lymphoma cells.
MedLine Citation:
PMID:  672925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unfiltered broad spectrum radiation emitted by black light, cool white, and black light blue fluorescent lamps and a sunlamp, is both toxic and mutagenic to L5178Y mouse lymphoma cells when the cells are irradiated in phosphate-buffered saline. The increase in mutant frequency seen after exposure of the cells is linear throughout the range of exposures tested. The linear increase in mutagenesis is observed even at exposure levels which do not cause significant toxicity. To facilitate comparison of the differing rates of mutagenesis derived from exposure-response curves obtained for each light source, we have defined a parameter, joule-equivalent mutagenesis (jem), equal to mutants per 10(5) survivors per joule per square meter. Jem values are calculated using the integrated irradiance of each lamp. Based on jem values, the relative mutagenicity of the various lamps tested (compared with a germicidal ultraviolet lamp) is 3 x 10(-3) for the sunlamp, 1 x 10(-4) for the black light and cool white lamps, and 3 x 10(-5) for the black light blue lamp. The toxic and mutagenic effects of the lamps are in reasonable agreement with their relative spectral output from 290 to 330 nm.
Authors:
E D Jacobson; K Krell; M J Dempsey; M H Lugo; O Ellingson; C W Hench
Related Documents :
20802695 - Blue-green laser-induced fluorescence from intact leaves: actinic light sensitivity and...
15925535 - Fluorescent identification of biological and other stains on skin by the use of alterna...
21480755 - Judgments about forces in described interactions between objects.
1916325 - Lens fluorometry: light-attenuation effects and estimation of total lens transmittance.
15142955 - Parieto-premotor areas mediate directional interference during bimanual movements.
18757235 - Skull tap induced vestibular evoked myogenic potentials: an ipsilateral vibration respo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  51     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-30     Completed Date:  1978-09-30     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  61-75     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Line
Dose-Response Relationship, Radiation
Light* / adverse effects
Lymphoma
Mutation*
Neoplasms, Experimental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike...
Next Document:  A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carci...