Document Detail

Toxicity and mutagenicity of hexavalent chromium on Salmonella typhimurium.
MedLine Citation:
PMID:  326184     Owner:  NLM     Status:  MEDLINE    
Four hexavalent and two trivalent chromium compounds were tested for toxicity and mutagenicity by means of the Salmonella typhimurium/mammalian-microsome test. All hexavalent compounds yielded a complete inhibition of bacterial growth at doses of 400 to 800 mug/plate, a significant increase of his(+) revertant colonies at doses ranging from 10 to 200 mug, and no effect at doses of less than 10 mug. The distinctive sensitivity of the four Salmonella strains tested (TA1535, TA1537, TA98, and TA100) suggested that hexavalent chromium directly interacts with bacterial deoxyribonucleic acid by causing both frameshift mutations and basepair substitutions. The latter mutations, which are prevalent, are amplified by an error-prone recombinational repair of the damaged deoxyribonucleic acid. On the average, 1 mumol of hexavalent chromium yielded approximately 500 revertants of the TA100 strain, irrespective of the compound tested (sodium dichromate, calcium chromate, potassium chromate, or chromic acid). The mutagenic potency of the hexavalent metal was not enhanced by adding the microsomal fraction of rat hepatocytes, induced either with sodium barbital or with Aroclor 1254. The two trivalent compounds (chromium potassium sulfate and chromic chloride), with or without the microsomal fraction, were neither toxic nor mutagenic for the bacterial tester strains.
F L Petrilli; S De Flora
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  33     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-9     Citation Subset:  IM    
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MeSH Terms
Chromates / pharmacology
Chromium / pharmacology*
Potassium Dichromate / pharmacology
Salmonella typhimurium / drug effects*,  growth & development
Reg. No./Substance:
0/Chromates; 0/Mutagens; 7440-47-3/Chromium; 7778-50-9/Potassium Dichromate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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