Document Detail


Toxicity of methimazole on femoral bone in suckling rats: Alleviation by selenium.
MedLine Citation:
PMID:  20833006     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIMS: Selenium has a pharmacological properties and it is well considered as an antioxidant. The present study investigated the potential ability of selenium, used as a nutritional supplement, to alleviate bone impairments in suckling rats whose mothers were treated with methimazole, an antithyroid drug.
MAIN METHODS: Female Wistar rats were randomly divided into four groups of six each: group I served as control which received standard diet; group II were rendered hypothyroid by administration of methimazole (250mgL(-1) in their drinking water); group III received both methimazole (250mgL(-1) in their drinking water) and selenium (0.5mgkg(-1) of diet); group IV received 0.5Na(2)SeO(3)mgkg(-1) of diet. Treatments were started from the 14th day of pregnancy until day 14 after delivery.
KEY FINDINGS: Methimazole treatment decreased femur length and weight in 14-day-old rats, when compared to controls. Femur antioxidant enzyme activities, superoxide dismutase, catalase and glutathione peroxidase decreased. Lipid peroxidation recorded an increase revealed by high femur malondialdehyde levels. Methimazole also caused a significant decrease in calcium and phosphorus levels in bone. Yet, in plasma and urine, they increased and decreased inversely. Besides, plasma total tartrate-resistant acid phosphatase was enhanced, while total alkaline phosphatase was reduced. Co-administration of selenium through diet improved the biochemical parameters cited above. Nevertheless, distorted histoarchitecture revealed in hypothyroid rat femur was alleviated by Se treatment.
SIGNIFICANCE: The present study suggests that selenium is an important protective element that may be used as a dietary supplement protecting against bone impairments.
Authors:
Ibtissem Ben Amara; Afef Troudi; Nejla Soudani; Fadhel Guermazi; Najiba Zeghal
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Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  64     ISSN:  1618-1433     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Animal Physiology Laboratory, Sfax Faculty of Science, BP 1171, 3000 Sfax, Tunisia.
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