| Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue. | |
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MedLine Citation:
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PMID: 14667476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examines the effects of a hypercaloric diet on hepatic glucose metabolism of young rats, with and without monosodium glutamate (MSG) administration, and the association of these treatments with evaluating markers of oxidative stress. Male weaned Wistar rats (21 days old) from mothers fed with a hypercaloric diet or a normal diet, were divided into four groups (n=6): control (C) fed with control diet; (MSG) treated with MSG (4 mg/g) and control diet; (HD) fed with hypercaloric diet and (MSG-HD) treated with MSG and HD. Rats were sacrificed after the oral glucose tolerance test (OGTT), at 45 days of treatments. Serum was used for insulin determination. Glycogen, hexokinase(HK), glucose-6-phosphatase(G6PH), lipid hydroperoxide, superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) were determined in liver. HD rats showed hypoglycemia, hyperinsulinemia, and high hepatic glycogen, HK and decreased G6PH. MSG and MSG-HD had hyperinsulinemia, hyperglycemia, decreased HK and increased G6PH in hepatic tissue. These animals had impaired OGTT. HD, MSG and MSG-HD groups had increased lipid hydroperoxide and decreased SOD in hepatic tissue. Hypercaloric diet and monosodium glutamate administration induced alterations in metabolic rate of glucose utilization and decreased antioxidant defenses. Therefore, the hepatic glucose metabolic shifting induced by HD intake and MSG administration were associated with oxidative stress in hepatic tissue. |
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Authors:
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Yeda S Diniz; Ana A H Fernandes; Kleber E Campos; Fernanda Mani; Bartolomé O Ribas; Ethel L B Novelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 42 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2003-12-11 Completed Date: 2004-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 313-19 Citation Subset: IM |
Affiliation:
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Post Graduation Course Department of Clinical and Cardiology, Faculty of Medicine, UNESP, Botucatu, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Diet* Female Flavoring Agents / administration & dosage, pharmacology* Glucose / metabolism* Insulin / blood Liver / metabolism* Male Oxidative Stress / drug effects Rats Rats, Wistar Sodium Glutamate / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Flavoring Agents; 11061-68-0/Insulin; 142-47-2/Sodium Glutamate; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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