| Toxicity of fatty acid 18:5n3 from Gymnodinium cf. mikimotoi: I. Morphological and biochemical aspects on Dicentrarchus labrax gills and intestine. | |
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MedLine Citation:
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PMID: 10439343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present evidence for the toxic effects of fatty acid 18:5n3 (octadecapentaenoic acid) in the gills and intestine of the sea bass Dicentrarchus labrax. Light microscopic observation of gills showed strong mucus production and alteration of ionocytes. The Mg- and Na,K-ATPase activities were inhibited, with IC50 values of 10(-3) and 1.6 x 10(-4) M, respectively. Results are discussed in relation to osmoregulation. |
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Authors:
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F Sola; A Masoni; B Fossat; J Porthé-Nibelle; P Gentien; G Bodennec |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 19 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 1999 Jul-Aug |
Date Detail:
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Created Date: 1999-09-28 Completed Date: 1999-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 279-84 Citation Subset: IM |
Affiliation:
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LPTE, Université de Nice-Sophia Antipolis, France. sola@unice.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bass* / metabolism Ca(2+) Mg(2+)-ATPase / antagonists & inhibitors Dinoflagellida / chemistry* Enzyme Inhibitors / toxicity Epithelial Cells / drug effects, pathology Fatty Acids, Unsaturated / isolation & purification, toxicity* Gills / drug effects*, enzymology, pathology Intestines / drug effects*, enzymology, pathology Microsomes / drug effects, enzymology Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Fatty Acids, Unsaturated; EC 3.6.1.-/Ca(2+) Mg(2+)-ATPase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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