| Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow. | |
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MedLine Citation:
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PMID: 16709433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Water-soluble fullerene (nC60) has been shown to induce lipid peroxidation (LPO) in brain of juvenile largemouth bass (LMB, Micropterus salmoides) [Oberdörster, E., 2004. Manufactured nanomaterials (fullerenes, c60) induce oxidative stress in brain of juvenile largemouth bass. Environ. Health Persp. 112, 1058-1062]; and upregulate genes related to the inflammatory response and metabolism, most notably CYP2K4 [. Nanotoxicology: an emerging discipline evolving from 116 studies of ultrafine particles. Environ. Health Persp. 113, 823-839]. The initial study in LMB was performed using tetrahydrofuran (THF)-solubilized nC60, although C60 can also be solubilized by stirring in water. The current study investigates differences in acute toxicity to Daphnia magna between THF-solubilized and water-stirred-nC60 as a range-find for further assays in adult male fathead minnow (FHM, Pimephales promelas). The daphnia 48-h LC50 for THF-nC60 was at least one order of magnitude less (0.8 ppm) than that for water-stirred-nC60 (> 35 ppm). FHM were dosed with either 0.5 ppm of THF- or water-stirred-nC60 for 48 h. There was 100% mortality in the THF-nC60-exposed fish between 6 and 18 h, while the water-stirred-nC60-exposed fish showed no obvious physical effects after 48 h. Water-stirred-nC60 elevated LPO in brain, significantly increased LPO in gill, and significantly increased expression of CYP2 family isozymes in liver as compared to control fish. |
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Authors:
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Shiqian Zhu; Eva Oberdörster; Mary L Haasch |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-04-22 |
Journal Detail:
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Title: Marine environmental research Volume: 62 Suppl ISSN: 0141-1136 ISO Abbreviation: Mar. Environ. Res. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-19 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882895 Medline TA: Mar Environ Res Country: England |
Other Details:
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Languages: eng Pagination: S5-9 Citation Subset: IM |
Affiliation:
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Environmental Toxicology Research Program, National Center for Natural Products Research, Department of Pharmacology, School of Pharmacy, The University of Mississippi, 347 Faser, University, MS 38677-1848, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Cyprinidae / metabolism* Daphnia / drug effects* Environmental Exposure* Fish Proteins / biosynthesis, drug effects Fullerenes / toxicity* Gills / drug effects, physiology Lethal Dose 50 Lipid Peroxidation / drug effects Male Manufactured Materials Survival Analysis Time Factors Water Pollutants / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Fish Proteins; 0/Fullerenes; 0/Water Pollutants; 99685-96-8/fullerene C60 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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