Document Detail

Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow.
MedLine Citation:
PMID:  16709433     Owner:  NLM     Status:  MEDLINE    
Water-soluble fullerene (nC60) has been shown to induce lipid peroxidation (LPO) in brain of juvenile largemouth bass (LMB, Micropterus salmoides) [Oberdörster, E., 2004. Manufactured nanomaterials (fullerenes, c60) induce oxidative stress in brain of juvenile largemouth bass. Environ. Health Persp. 112, 1058-1062]; and upregulate genes related to the inflammatory response and metabolism, most notably CYP2K4 [. Nanotoxicology: an emerging discipline evolving from 116 studies of ultrafine particles. Environ. Health Persp. 113, 823-839]. The initial study in LMB was performed using tetrahydrofuran (THF)-solubilized nC60, although C60 can also be solubilized by stirring in water. The current study investigates differences in acute toxicity to Daphnia magna between THF-solubilized and water-stirred-nC60 as a range-find for further assays in adult male fathead minnow (FHM, Pimephales promelas). The daphnia 48-h LC50 for THF-nC60 was at least one order of magnitude less (0.8 ppm) than that for water-stirred-nC60 (> 35 ppm). FHM were dosed with either 0.5 ppm of THF- or water-stirred-nC60 for 48 h. There was 100% mortality in the THF-nC60-exposed fish between 6 and 18 h, while the water-stirred-nC60-exposed fish showed no obvious physical effects after 48 h. Water-stirred-nC60 elevated LPO in brain, significantly increased LPO in gill, and significantly increased expression of CYP2 family isozymes in liver as compared to control fish.
Shiqian Zhu; Eva Oberdörster; Mary L Haasch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-04-22
Journal Detail:
Title:  Marine environmental research     Volume:  62 Suppl     ISSN:  0141-1136     ISO Abbreviation:  Mar. Environ. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882895     Medline TA:  Mar Environ Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  S5-9     Citation Subset:  IM    
Environmental Toxicology Research Program, National Center for Natural Products Research, Department of Pharmacology, School of Pharmacy, The University of Mississippi, 347 Faser, University, MS 38677-1848, USA.
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MeSH Terms
Brain / drug effects,  metabolism
Cyprinidae / metabolism*
Daphnia / drug effects*
Environmental Exposure*
Fish Proteins / biosynthesis,  drug effects
Fullerenes / toxicity*
Gills / drug effects,  physiology
Lethal Dose 50
Lipid Peroxidation / drug effects
Manufactured Materials
Survival Analysis
Time Factors
Water Pollutants / toxicity*
Reg. No./Substance:
0/Fish Proteins; 0/Fullerenes; 0/Water Pollutants; 99685-96-8/fullerene C60

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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