| Toxicity of chloroform extract of prunus africana stem bark in rats: gross and histological lesions. | |
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MedLine Citation:
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PMID: 12164269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chloroform extract of Prunus africana (Hook f. (Rosaceae) did not cause clinical signs or pathology in rats at daily oral doses of up to 1,000 mg/kg for 8 weeks. The extract caused marked clinical signs, organ damage and a 50% mortality rate at a dose of 3.3 g/kg for 6 days. The main lesions observed at this dose were marked centrilobular hepatocellular degeneration and necrosis, diffuse nephrosis, myocardial degeneration, lymphocytic necrosis and neuronal degeneration. The morphological damage in these tissues caused a corresponding rise in blood biochemical parameters namely, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatine kinase and blood urea nitrogen. The target organs of toxicity of this extract are the liver, kidney and heart. Overt toxicity occurred only after the administration of multiple doses of 3.3 g/kg body weight. These findings confirm the suitability of this extract for therapeutic use, since the doses used in the therapy of prostate gland are much lower than those used in this study and would therefore not be expected to cause pathological changes. |
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Authors:
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P K Gathumbi; J W Mwangi; G M Mugera; S M Njiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 16 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-08-07 Completed Date: 2003-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathology and Microbiology, University of Nairobi, Kenya. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood,
drug effects Alkaline Phosphatase / blood, drug effects Animals Aspartate Aminotransferases / blood, drug effects Blood Urea Nitrogen Chloroform / chemistry Creatine Kinase / blood, drug effects Heart / drug effects Kidney / drug effects, pathology L-Lactate Dehydrogenase / blood, drug effects Liver / drug effects, pathology Male Myocardium / pathology Organ Size / drug effects Plant Bark / chemistry* Plant Extracts / toxicity* Plant Stems / chemistry Pygeum* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 67-66-3/Chloroform; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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