Document Detail


Toxicity of adipic acid.
MedLine Citation:
PMID:  12024802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adipic acid has very low acute toxicity in rats with an LD50 > 5000 mg/kg. Adipic acid produced mild to no skin irritation on intact guinea pig skin as a 50% concentration in propylene glycol; it was not a skin sensitizer. Adipic acid caused mild conjunctival irritation in washed rabbit eyes; in unwashed rabbit eyes, there was mild conjunctival irritation, minimal iritis, but no corneal effects. Adipic acid dust may irritate the mucous membranes of the lungs and nose. In a 2-year feeding study, rats fed adipic acid at concentrations up to 5% in the diet exhibited only weight loss. Adipic acid is not genetically active in a wide variety of assay systems. Adipic acid caused no developmental toxicity in mice, rats, rabbits, or hamsters when administered orally. Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests.
Authors:
Gerald L Kennedy
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  25     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-11-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-202     Citation Subset:  IM    
Affiliation:
Haskell Laboratory, DuPont Company, 1090 Elkton Road, Newark, DE 19714, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipic Acids / metabolism,  toxicity*
Animals
Dose-Response Relationship, Drug
Ecosystem
Environmental Pollutants / toxicity
Food Additives / toxicity*
Guinea Pigs
Humans
Mice
Occupational Exposure*
Rabbits
Rats
Toxicity Tests*
Chemical
Reg. No./Substance:
0/Adipic Acids; 0/Environmental Pollutants; 0/Food Additives; 124-04-9/adipic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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