Document Detail

Toxicity study of ethanolic extract of Chrysanthemum morifolium in rats.
MedLine Citation:
PMID:  20722958     Owner:  NLM     Status:  MEDLINE    
Chrysanthemum morifolium extract (CME) has many pharmacological effects, and the effective components of CME are luteolin and apigenin which have been reported with cytotoxicity in vitro. The purpose of this study was to evaluate the safety of CME in Sprague-Dawley (S-D) rats. In the acute toxicity study, a single oral dose of 15 g/kg body weight (bw) CME was administered to rats, then the rats were observed for 14 d. No treatment-related death was observed, and the maximal tolerance dose estimated was greater than 15 g/kg bw in rats. In the long-term toxicity study, the rats were administered daily by gavage at dose levels of 320, 640, and 1280 mg/kg bw/d for consecutive 26 wk followed by 4 wk recovery period. The results showed that no toxicological changes in body weight, food, and water consumption, hematologic examination, blood biochemical examination, organ weight, and microscopic histopathologic examination were found in any treatment group. Therefore, CME is considered to be safe in general in rats at the limited dose level.
Liping Li; Liqiang Gu; Zhongjian Chen; Ruwei Wang; Jianfeng Ye; Huidi Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  T105-9     Citation Subset:  IM    
Dept. of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang Univ., Hangzhou, P.R. China.
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MeSH Terms
Apigenin / analysis
Chrysanthemum / chemistry*
Drugs, Chinese Herbal / chemistry,  toxicity*
Flowers / chemistry*
Luteolin / analysis
Maximum Tolerated Dose
Random Allocation
Rats, Sprague-Dawley
Toxicity Tests, Chronic
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Solvents; 491-70-3/Luteolin; 520-36-5/Apigenin; 64-17-5/Ethanol

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