Document Detail


Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines.
MedLine Citation:
PMID:  2175958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trichosanthin and alpha-momorcharin are abortifacient proteins extracted from Chinese medicinal herbs. Study of their in vitro cytotoxicities showed that the two proteins selectively injured choriocarcinoma and melanoma cells. Hepatoma cells represented the most resistant cell line among the various cell lines investigated. Cytotoxicity profiles of trichosanthin and alpha-momorcharin differed from those of anti-cancer drugs which interfere with DNA metabolism such as cisplatin, methotrexate and 5-fluorouracil. Radioactive precursor incorporation studies suggested that the two abortifacient proteins inhibited cellular protein synthesis. The marked decrease in secretion of human chorionic gonadotrophin and progesterone by choriocarcinoma cells after treatment with the proteins could be attributed mainly to loss of cells.
Authors:
S W Tsao; T B Ng; H W Yeung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  28     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-04     Completed Date:  1991-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1183-92     Citation Subset:  IM; X    
Affiliation:
Department of Anatomy, Chinese University of Hong Kong, Shatin.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / toxicity*
Animals
Carcinoma, Hepatocellular
Carcinoma, Squamous Cell
Cell Division / drug effects*
Cell Line
Choriocarcinoma
Chorionic Gonadotropin / secretion
Cisplatin / toxicity
Drugs, Chinese Herbal / toxicity*
Fluorouracil / toxicity
Humans
Liver Neoplasms
Melanoma
Methotrexate / toxicity
Plant Proteins / toxicity*
Progesterone / secretion
Ribosomal Proteins*
Ribosome Inactivating Proteins
Trichosanthin / toxicity*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 0/Drugs, Chinese Herbal; 0/Plant Proteins; 0/Ribosomal Proteins; 15663-27-1/Cisplatin; 51-21-8/Fluorouracil; 57-83-0/Progesterone; 59-05-2/Methotrexate; 60318-52-7/Trichosanthin; 88026-31-7/MMC protein, Momordica charantia; EC 3.2.2.22/Ribosome Inactivating Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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