Document Detail

Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines.
MedLine Citation:
PMID:  2175958     Owner:  NLM     Status:  MEDLINE    
Trichosanthin and alpha-momorcharin are abortifacient proteins extracted from Chinese medicinal herbs. Study of their in vitro cytotoxicities showed that the two proteins selectively injured choriocarcinoma and melanoma cells. Hepatoma cells represented the most resistant cell line among the various cell lines investigated. Cytotoxicity profiles of trichosanthin and alpha-momorcharin differed from those of anti-cancer drugs which interfere with DNA metabolism such as cisplatin, methotrexate and 5-fluorouracil. Radioactive precursor incorporation studies suggested that the two abortifacient proteins inhibited cellular protein synthesis. The marked decrease in secretion of human chorionic gonadotrophin and progesterone by choriocarcinoma cells after treatment with the proteins could be attributed mainly to loss of cells.
S W Tsao; T B Ng; H W Yeung
Related Documents :
9113088 - Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in hct-...
21622128 - Nadph treatment decreases c6 glioma cell survival by increasing oxidative stress.
3258308 - Biochemical and molecular properties of cisplatin-resistant a2780 cells grown in folini...
10609558 - Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction.
2854028 - Stalk cell formation in monolayers of dictyostelium discoideum v12-m2.
9020398 - An ultrastructural evaluation of acute 1-nitronaphthalene induced hepatic and pulmonary...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  28     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-04     Completed Date:  1991-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1183-92     Citation Subset:  IM; X    
Department of Anatomy, Chinese University of Hong Kong, Shatin.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortifacient Agents, Nonsteroidal / toxicity*
Carcinoma, Hepatocellular
Carcinoma, Squamous Cell
Cell Division / drug effects*
Cell Line
Chorionic Gonadotropin / secretion
Cisplatin / toxicity
Drugs, Chinese Herbal / toxicity*
Fluorouracil / toxicity
Liver Neoplasms
Methotrexate / toxicity
Plant Proteins / toxicity*
Progesterone / secretion
Ribosomal Proteins*
Ribosome Inactivating Proteins
Trichosanthin / toxicity*
Tumor Cells, Cultured
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 0/Drugs, Chinese Herbal; 0/Plant Proteins; 0/Ribosomal Proteins; 15663-27-1/Cisplatin; 51-21-8/Fluorouracil; 57-83-0/Progesterone; 59-05-2/Methotrexate; 60318-52-7/Trichosanthin; 88026-31-7/MMC protein, Momordica charantia; EC Inactivating Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bimodal operation of the ryanodine-sensitive transducer calcium channel.
Next Document:  Effects of cocaine on pial arterioles in cats.