Document Detail


Toxic-therapeutic ratio of sodium cyanate.
MedLine Citation:
PMID:  1156065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO-/mol of hemoglobin: six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extra-corporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.
Authors:
S Charache; T P Duffy; N Jander; J C Scott; M Bedine; R Morrell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  135     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1043-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / drug therapy,  therapy
Animals
Blood Transfusion
Cyanates / administration & dosage*,  poisoning,  therapeutic use
Female
Humans
Male
Neural Conduction / drug effects
Rats
Chemical
Reg. No./Substance:
0/Cyanates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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