Document Detail


Toxic shock syndrome caused by hospital-acquired methicillin-resistant Staphylococcus aureus in a patient with pancytopenia.
MedLine Citation:
PMID:  20196714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxic shock syndrome is an uncommon condition in patients with neutropenia. We describe a 44-year-old man who developed toxic shock syndrome caused by hospitalacquired methicillin-resistant Staphylococcus aureus while pancytopenic after chemotherapy. He died of multiorgan failure despite high-level intensive care support and treatment with appropriate antibiotics and intravenous immunoglobulin. This case illustrates the need for a high index of suspicion for toxic shock syndrome in patients with febrile neutropenia, and also highlights the lack of highquality evidence for the various treatment modalities used in this syndrome.
Authors:
Benoj Varghese; Ritesh Sanghavi; Amjed Aziz; Iain B Gosbell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine     Volume:  12     ISSN:  1441-2772     ISO Abbreviation:  Crit Care Resusc     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888170     Medline TA:  Crit Care Resusc     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
Affiliation:
Department of Intensive Care Medicine, Liverpool Hospital, Sydney, NSW.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Cross Infection / drug therapy,  microbiology*
Cytarabine / administration & dosage,  adverse effects
Etoposide / administration & dosage,  adverse effects
Fatal Outcome
Humans
Idarubicin / administration & dosage,  adverse effects
Leukemia, Myeloid, Acute / complications,  drug therapy
Male
Methicillin-Resistant Staphylococcus aureus*
Multiple Organ Failure
Pancytopenia / chemically induced,  immunology
Shock, Septic / drug therapy,  microbiology*
Staphylococcal Infections / drug therapy,  microbiology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 147-94-4/Cytarabine; 33419-42-0/Etoposide; 58957-92-9/Idarubicin

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