| Toxic reactions evoked by glutaraldehyde-fixed pericardium and cardiac valve tissue bioprosthesis. | |
| | |
MedLine Citation:
|
PMID: 6085799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bovine pericardial tissue and tissue-derived bioprosthesis fixed in glutaraldehyde and stored in either glutaraldehyde or formaldehyde can induce cytotoxic reactions even after prolonged washing due to the slow leaching of the chemicals used for crosslinking and sterilizing. Sequential rinsing for up to 60 min was still not sufficient to eliminate cytotoxic effects. On the other hand, satisfactory results were obtained when cardiac valves made from glutaraldehyde fixed pericardium were stored in a solution containing 0.02% of propyl-hydroxy-benzoate and 0.18% methyl-hydroxy-benzoate. The valves stored in this solution and rinsed three times for 1 min in normal saline showed few signs of residual cytotoxicity. Rinsing in a solution containing glycine was partially effective in neutralizing the cytotoxic effect, and this or similar approaches offer good possibilities. The use of Chang cells grown in culture provides an excellent quantitative assay for the assessment of residual cytotoxicity and for evaluating the host response to different methods of fixation, storage, and rinsing of tissue derived bioprosthesis. |
| | |
Authors:
|
E Gendler; S Gendler; M E Nimni |
Related Documents
:
|
15597369 - Recovery of periodontopathogenic bacteria from embalmed human cadavers. 12146829 - The accidental sinking of the nuclear submarine, the kursk: monitoring of radioactivity... 23633959 - Correction: molecular networks of human muscle adaptation to exercise and age. 9874149 - A non-radioactive in situ hybridization method that does not require rnase-free conditi... 12448469 - The effect of aeration and non-aeration time on simultaneous organic, nitrogen and phos... 14627299 - Microbial and sensory quality of marinated and irradiated chicken. 8335569 - Hypoxic potentiation of the ventilatory response to dynamic forearm exercise. 1928769 - Physiologic responses to mild perianesthetic hypothermia in humans. 2295379 - Morphological and biochemical examination of cosmos 1887 rat heart tissue: part i--ultr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of biomedical materials research Volume: 18 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1984 Sep |
Date Detail:
|
Created Date: 1985-12-30 Completed Date: 1985-12-30 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 727-36 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldehydes
/
toxicity* Animals Bioprosthesis / adverse effects* Cattle Chemistry, Physical Glutaral / toxicity* Heart Valve Prosthesis / adverse effects* Mice Pericardium / pathology* Physicochemical Phenomena Staining and Labeling Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Aldehydes; 111-30-8/Glutaral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modification of polyetherurethane for biomedical application by radiation induced grafting. II. Wate...
Next Document: Marginal leakage of class V cavity preparations.