| Toxic nuclear effects of the organophosphorus insecticide Dichlorvos (DDVP) in human peripheral blood lymphocytes. | |
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MedLine Citation:
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PMID: 20015832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organophosphorus insecticides are used worldwide in the control of agricultural, household and veterinary pests. Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is a commonly used organophosphorus insecticide. In this study, in order to elucidate the toxic nuclear effects of dichlorvos, freshly isolated human peripheral blood lymphocytes were incubated with 5, 10, 20, 40, 80 and 100 microg/mL of dichlorvos. According to the results, dichlorvos induced micronuclei, decreased the mitotic and replication indexes. It is a genotoxic product causing chromosomal damage (an increase in micronucleus) and cell death (decrease in mitotic and replication indexes). |
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Authors:
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H E Ero?lu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta biologica Hungarica Volume: 60 ISSN: 0236-5383 ISO Abbreviation: Acta. Biol. Hung. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404358 Medline TA: Acta Biol Hung Country: Hungary |
Other Details:
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Languages: eng Pagination: 409-16 Citation Subset: IM |
Affiliation:
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Bozok University Department of Biology, Faculty of Science and Art Yozgat Turkey. herhan.eroglu@bozok.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Death
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drug effects Cell Division / drug effects Cell Nucleus / drug effects*, pathology* Cells, Cultured Chromosomes / drug effects Dichlorvos / pharmacology* Dose-Response Relationship, Drug Female Humans Insecticides / pharmacology* Leukocytes, Mononuclear / drug effects*, pathology* Male Mitosis / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Insecticides; 62-73-7/Dichlorvos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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