Document Detail

Toxic neonatal effects following maternal clomipramine therapy.
MedLine Citation:
PMID:  1749054     Owner:  NLM     Status:  MEDLINE    
Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1). The drug is widely prescribed in Europe and Canada and has been recently approved for use in the USA. Its safety during pregnancy and breastfeeding, however, has not been fully established. Very few reports on its effect on the fetus and neonate have been published (2,3). We report a case of a mother treated with clomipramine during pregnancy, and the side effects observed in the infant. The correlation between plasma clomipramine concentrations in the baby's blood and clinical effects are described. Subsequently, we present the pregnancy outcome of five prospectively collected cases.
M S Schimmell; E Z Katz; Y Shaag; A Pastuszak; G Koren
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  29     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  AIM; IM    
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Akathisia, Drug-Induced
Bottle Feeding
Breast Feeding
Clomipramine / adverse effects*,  pharmacokinetics,  therapeutic use
Depressive Disorder / drug therapy*
Infant, Newborn
Milk / analysis
Muscle Hypotonia / chemically induced
Pregnancy Complications / drug therapy*
Pregnancy Outcome*
Prospective Studies
Respiration / drug effects
Tremor / chemically induced
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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