Document Detail

Toxic leukoencephalopathy: a review and report of two chemotherapy-related cases.
MedLine Citation:
PMID:  12929274     Owner:  NLM     Status:  MEDLINE    
Leukoencephalopathy syndrome is a rare disorder that results from structural alterations of cerebral white matter, is characterized by cerebral edema, and can occur in patients of any age. Cranial irradiation and certain chemotherapy agents, especially those used in high-dose protocols, are causal agents. The prevalence of toxic leukoencephalopathy is unknown; however, this syndrome has been reported increasingly in the literature in patients who develop neurobehavioral changes following exposure to various toxins. Diagnosis must confirm exposure to a toxin and the presence of neurobehavioral deficits and neuroradiologic abnormalities. In most reported cases, clinical symptoms are reversible after the offending toxin is withdrawn. This article describes two cases of chemotherapy-related leukoencephalopathy and reviews the nursing care of patients experiencing this syndrome.
Diana Moore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical journal of oncology nursing     Volume:  7     ISSN:  1092-1095     ISO Abbreviation:  Clin J Oncol Nurs     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9705336     Medline TA:  Clin J Oncol Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  N    
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MeSH Terms
Antineoplastic Agents / adverse effects*
Brain / drug effects,  pathology
Leukoencephalopathy, Progressive Multifocal / chemically induced*
Magnetic Resonance Imaging
Neoplasms / drug therapy*
Nursing / methods*
Reg. No./Substance:
0/Antineoplastic Agents

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