Document Detail

Toxic leukoencephalopathy in the intensive care unit.
MedLine Citation:
PMID:  25342412     Owner:  NLM     Status:  Publisher    
In this article, we report two cases of acute toxic leukoencephalopathy to highlight this acute clinicoradiological syndrome as an important, although uncommon, consideration in the undifferentiated comatose patient who fails to wake following drug overdose or has unexplained neurology with a history of drug exposure. We then review the current literature and discuss potential differential diagnoses in this setting, along with proposed treatments for this condition. The cases presented demonstrate a more fulminant onset than previously well-defined acute toxic leukoencephalopathy subtypes and highlight the prognostic importance of magnetic resonance imaging in diagnosing a condition from which significant functional recovery seems possible.
A L Holyoak; M J Trout; R P White; S Prematuranga; S Senthuran
Publication Detail:
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  42     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-10-24     Completed Date:  -     Revised Date:  2014-10-25    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  782-788     Citation Subset:  -    
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