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Toxic-inflammatory effects of prostoglandin analogs on the ocular surface.
MedLine Citation:
PMID:  23323576     Owner:  NLM     Status:  In-Data-Review    
Purpose: To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Materials and methods: Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no treatment. Dysplasia and keratinization were evaluated on the ocular surface. In the subepithelial area, the number of lymphocytes and mast cells were counted morphologically, and collagen staining densities were compared subjectively in groups. Results: The ratio of keratinization was 3/12 and 1/10, in groups I and II. The lymphocyte cell counts were 1.4 ± 0.19, 2.2 ± 0.39, 2.27 ± 0.33, and 1.87 ± 0.35 (p > .05). The mast cell counts were 2.58 ± 0.5, 5.4 ± 1.1, 5.7 ± 0.58, and 3.0 ± 0.59. They were significantly higher in groups II and III than in group I (p < .05). Mean collagen density scores were 1.00 ± 0.85, 2.00 ± 0.00, and 1,73 ± 0.70. Group II and III scores were higher than group I scores (p < .05). Conclusion: Latanoprost and travoprost seem to have more toxic-inflammatory effects on the ocular surface than bimatoprost.
Soner Demirel; Selim Doganay; Iclal Gurses; Mustafa Iraz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  21     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  IM    
Department of Ophthalmology, Inonu University, Faculty of Medicine , Malatya , Turkey.
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