Document Detail

Toxic hepatopathy in neonatal foals.
MedLine Citation:
PMID:  6710809     Owner:  NLM     Status:  MEDLINE    
Six foals of three different breeds, born to healthy mares, appeared normal at birth, and died at two to five days of age with icterus, ataxia, head pressing, and terminal hepatic coma. Their livers were less than one-half normal weight. Most of the liver was dark red-brown and slightly rubbery. Histologically, these areas were characterized by severe bile ductule proliferation, mild portal tract fibrosis, and massive hepatocellular necrosis and lobular collapse. A small proportion of the liver, usually on the peripheral part of the lobes, was grossly light brown and slightly raised. Histologically, these areas had mild to severe bile stasis in canaliculi. In the thin marginal zone between the severely affected and mildly affected liver, there was mild bile ductule proliferation and periportal fatty change and necrosis. Alzheimer's type II cells, characteristic of hepatoencephalopathy, were numerous in the brains of all foals. Within two hours after birth, all the foals had been given an oral proprietary nutritional paste, the ingredients of which included a viable Aspergillus sp and an iron compound. Similar lesions were produced in an experimental foal.
H M Acland; P C Mann; J L Robertson; T J Divers; C A Lichtensteiger; R H Whitlock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  21     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-05-24     Completed Date:  1984-05-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn*
Bile Ducts / pathology
Brain / pathology
Cell Division
Disease Outbreaks / veterinary*
Drug-Induced Liver Injury / pathology,  veterinary*
Hepatic Encephalopathy / pathology,  veterinary*
Horse Diseases / pathology*
Liver / pathology,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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