Document Detail

Toxic etiology of aplastic anemia. The Cooperative Study Group for Aplastic and Refractory Anemias.
MedLine Citation:
PMID:  6523314     Owner:  NLM     Status:  MEDLINE    
In this retrospective investigation into the possible causes of aplastic anemia, the charts of 360 patients with primary or secondary aplastic anemia were analyzed for clinical history, proof of diagnosis, possible etiology, and prognostic criteria. During the period of the study, the proportion of cases of aplastic anemia due to chloramphenicol, benzene, butazone, and sulfonamides decreased, whereas the proportion due to gold salts, penicillamine, amidopyrine, and trimethoprim-sulfamethoxazole increased. No case of secondary aplastic anemia in recent years could be attributed with certainty to thiamphenicol; one possible case of thiamphenicol-induced aplastic anemia could have been due to exposure to other chemicals known to cause aplastic anemia. The disease course and mortality rate for secondary aplastic anemia are similar to those for primary aplastic anemia. The results of this study show the need for more careful investigation into the causes of all cases of aplastic anemia attributed to toxic agents or environmental factors.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  11     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:    1984 Oct-Dec
Date Detail:
Created Date:  1985-03-15     Completed Date:  1985-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
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MeSH Terms
Actuarial Analysis
Anemia, Aplastic / chemically induced*,  mortality
Chloramphenicol / adverse effects
Retrospective Studies
Thiamphenicol / adverse effects*
Reg. No./Substance:
15318-45-3/Thiamphenicol; 56-75-7/Chloramphenicol

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