Document Detail

Toxic epidermal necrolysis--an unusual cause of colonic perforation. Report of a case.
MedLine Citation:
PMID:  8348869     Owner:  NLM     Status:  MEDLINE    
Toxic epidermal necrolysis (TEN) is a rare and severe reaction to certain drugs that results in full-thickness epidermal necrosis of the skin. Other mucosal surfaces such as the oropharynx, esophagus, conjunctiva, and genitalia may also be affected. Specific involvement of the colon is distinctly unusual. A case of TEN that resulted in complete small bowel necrosis and colonic perforation is reported. Early and aggressive surgical resection dealt successfully with this complication and, along with supportive care, allowed resolution of the systemic condition to occur. Five additional cases of colonic necrosis complicating TEN are reviewed.
F M Carter; C K Mitchell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  36     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-14     Completed Date:  1993-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-7     Citation Subset:  IM    
Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina 27858.
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MeSH Terms
Colonic Diseases / etiology*,  surgery
Epidermal Necrolysis, Toxic / complications*
Intestinal Perforation / etiology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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