Document Detail

Toxic epidermal necrolysis in a premature infant of 27 weeks' gestational age.
MedLine Citation:
PMID:  15656816     Owner:  NLM     Status:  MEDLINE    
Toxic epidermal necrolysis (TEN) is very rare in the newborn period. So far, three cases of TEN in newborns have been reported worldwide. We report a premature infant of 27 weeks' gestational age with TEN at 4 weeks of age. Sepsis treated by an antibiotic combination regimen preceding the TEN was a common feature of all four cases. In our patient, coagulase-negative staphylococci could be identified by blood culture, whereas the previously reported patients suffered from Klebsiella pneumoniae sepsis or Escherichia coli sepsis. Possibly, the uniform association with septic infection in the cases of TEN in the neonatal period might hint at a causal association, thus differentiating it from TEN in older children or adults.
K Lohmeier; M Megahed; K W Schulte; H Stannigel; E Mayatepek; H Schroten
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  152     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-19     Completed Date:  2005-04-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  150-1     Citation Subset:  IM    
Department of General Paediatrics, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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MeSH Terms
Anti-Bacterial Agents
Diseases in Twins / etiology*
Drug Therapy, Combination / adverse effects
Epidermal Necrolysis, Toxic / etiology*,  pathology
Fatal Outcome
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / etiology*,  pathology
Sepsis / complications
Staphylococcal Infections / complications
Reg. No./Substance:
0/Anti-Bacterial Agents

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