| Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to consider. | |
| | |
MedLine Citation:
|
PMID: 15015667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Toxic epidermal necrolysis (TEN) is an infrequent disease but with a high mortality rate. It is a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants. Many patients with primary or metastatic intracranial tumours receive anticonvulsants for seizure prophylaxis despite their efficacy not having been clearly demonstrated. Moreover, several cases have been reported in the literature in which serious adverse drug reactions such as TEN and Stevens-Johnson syndrome (SJS) have occurred following anticonvulsants exposure. In some of these cases the effect of radiation therapy and the tapering of steroid dose on the pathogenesis of these reactions have been highlighted. We report, here, a case of TEN that appeared in a patient receiving phenytoin, and shortly after the end of cranial and thoracic irradiation therapy for brain metastases of non-small cell lung cancer. Clinical considerations about diagnosis of SJS and TEN are presented. The use of prophylactic anticonvulsants is also discussed as well as a review of the literature. |
| | |
Authors:
|
David Aguiar; Roberto Pazo; Ignacio Durán; Josefa Terrasa; Antonio Arrivi; Herminio Manzano; Javier Martín; Julio Rifá |
Related Documents
:
|
8240027 - Neomycin--a frequent contact allergen. 10197137 - The prevalence of allergic rhinosinusitis: a review. 8469167 - Htlv-1 sequences in lymphocytes of a patient with non-tropical spastic tetraparesis and... 1611157 - Possible association of benzalkonium chloride in nebulizer solutions with respiratory a... 11422607 - Severe toxic hepatitis associated with amoxycillin and clavulanic acid. 21130607 - Confronting multidrug-resistant acinetobacter baumannii: a review. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of neuro-oncology Volume: 66 ISSN: 0167-594X ISO Abbreviation: J. Neurooncol. Publication Date: 2004 Feb |
Date Detail:
|
Created Date: 2004-03-12 Completed Date: 2004-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 345-50 Citation Subset: IM |
Affiliation:
|
Servicio de Oncología Médica, Hospital Universitario Son Dureta, Palma de Mallorca, Islas Baleares, Spain. dagubuj@gobiernodecanarias.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anticonvulsants
/
adverse effects* Brain Neoplasms / secondary, therapy Carcinoma, Non-Small-Cell Lung / secondary, therapy Cranial Irradiation / adverse effects* Epidermal Necrolysis, Toxic / diagnosis, etiology* Humans Lung Neoplasms / pathology, therapy Male Middle Aged Phenytoin / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ganglioneurocytoma of the third ventricle.
Next Document: Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in ...