Document Detail


Toxic effects of repeated oral exposure of silver nanoparticles on small intestine mucosa of mice.
MedLine Citation:
PMID:  23301827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract As the use of silver nanoparticles is increasing fast in industry, food, medicines, etc., exposure to silver nanoparticles is increasing in quantity day by day. So, it is imperative to know the adverse effects of silver nanoparticles in man. In this study, we selected mice as an animal model and observed the effect of silver nanoparticles on small intestinal mucosa. Silver nanoparticles ranging from 3-20nm were administered orally at a dose of 5 mg/kg, 10 mg/kg, 15 mg/kg, and 20 mg/kg body weight to the Swiss-albino male mice for 21 days. There was a significant decrease (P<0.05) in the body weight of mice in all the silver nanoparticles treated groups. Mice treated at a dose of 10 mg/kg showed the maximum weight loss. Effects were noted by using light microscopy as well as transmission electron microscopy. It was found that silver nanoparticles damage the epithelial cell microvilli as well as intestinal glands. It may be hypothesized that loss of microvilli reduced absorptive capacity of intestinal epithelium and hence weight loss.
Authors:
Brigesh Shahare; Madhu Yashpal; Gajendra Singh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Toxicology mechanisms and methods     Volume:  -     ISSN:  1537-6524     ISO Abbreviation:  Toxicol. Mech. Methods     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134521     Medline TA:  Toxicol Mech Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Electron Microscope Facility, Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, INDIA.
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