Document Detail


Toxic effects of cyclopiazonic acid in the early phase of pregnancy in mice.
MedLine Citation:
PMID:  3575873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reproductive toxicity of a single oral dose/mouse (15-50 mg/kg) of cyclopiazonic acid (CPA) in the early phase of pregnancy (day 2-8) was investigated. Male mice used in this study were untreated. A limited number of pregnant mice were treated with 66 mg/kg ergonovine maleate (po, sc) to compare its effect with that of an equivalent dose of CPA (50 mg/kg). Among control sperm-positive mice treated with po NaHCO3 solution, 97.5% were gravid on necropsy day (pregnancy day 12). A single dose of CPA (15-50 mg/kg, po) given on days 2 to 8, decreased the pregnancy rates significantly. In groups treated with a single dose of CPA on pregnancy day 4 to 8, vaginal hemorrhage was observed 1 to 7 days after treatment, and it usually resulted in termination of pregnancy (abortion). Fetal resorption rates were higher than the control rate only in the groups treated with 30 mg/kg CPA po on day 4 or 8. CPA decreased body weight gains and the weights of uteri with fetuses. The ovary weights were generally not changed. Ergonovine maleate (66 mg/kg, sc, po) had no significant effect on all of the parameters examined. The estrous cycle returned without any delay in sperm-positive mice in which nidation of fertilized eggs had been inhibited by CPA, and also in nonpregnant mice (used for the LD50 determination) surviving near lethal doses of CPA (50-70 mg/kg, po). The oral LD50 value for CPA in nonpregnant mice was 64 +/- 4.4 mg/kg, and the toxicity signs were ptosis, hypokinesia, hypothermia, action tremor, cessation of food and water intake and resulting cachexia. The duration and intensity of these toxic signs were dose dependent.
Authors:
K Nishie; R J Cole; J W Dorner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  55     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-12     Completed Date:  1987-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Body Temperature / drug effects
Body Weight / drug effects
Embryo Implantation / drug effects
Female
Indoles / toxicity*
Lethal Dose 50
Mice
Motor Activity / drug effects
Mycotoxins / toxicity*
Organ Size / drug effects
Pregnancy
Pregnancy, Animal / drug effects*
Reproduction / drug effects
Chemical
Reg. No./Substance:
0/Indoles; 0/Mycotoxins; 18172-33-3/cyclopiazonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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