| Toxic effects of cholelitholytic solvents on gallbladder and liver. A piglet model study. | |
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MedLine Citation:
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PMID: 7851209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the toxic effects of four currently used chemolytic solvents--dimethyl sulfoxide (DMSO, 99%), ethyl propionate (EP, 99%), tetrasodium ethyl-dimethyl tetraacetate (4Na-EDTA, 2%, pH 11), and methyl tert-butyl ether (MTBE, purity = 99.5%) in an animal model. Each solvent was tested in nine farm piglets (Landrace), weighing between 20 and 25 kg. A solvent-resistant catheter was inserted transhepatically into the gallbladder (GB) using sonographic guidance 24 hr prior to each experiment. Seventy-five milliliters of each solvent was infused over 3 hr into the gallbladder. The following day, a laparotomy was performed in order to assess for possible damage to the liver, GB, bile ducts (BD), or intestines. The GB and liver were resected and their histology examined. The following pathologic grades were assigned to GB, BD, and liver specimens to describe the tissue damage: normal (0), mild (1), moderate (2), and severe (3). We found that DMSO had the highest score on gallbladder and bile duct injury (49, 3), followed by EP (36, 2), EDTA (14, 1) and MTBE (16, 0), respectively; the difference in gallbladder damage was statistically significant. Very mild hepatocyte damage was present in the DMSO (2) and MTBE (2) groups. The administration of EP and EDTA resulted in no liver injury at all. Piglets within each treatment group suffered from varying degrees of tissue injury. No deaths were attributed to the administered solvents. We concluded that DMSO, EP, EDTA, and MTBE do not have serious local toxic effect on the GB, BD, and intestine; nor do they lead to severe hepatotoxicity.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C Y Chen; K K Chang; N H Chow; T C Leow; T C Chou; X Z Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 40 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 419-26 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholelithiasis / pathology, therapy* Dimethyl Sulfoxide / therapeutic use, toxicity Disease Models, Animal* Drug Evaluation, Preclinical Edetic Acid / therapeutic use, toxicity Ethers / therapeutic use, toxicity Gallbladder / drug effects*, pathology Liver / drug effects*, pathology Methyl Ethers* Propionates / therapeutic use, toxicity Solvents / therapeutic use, toxicity* Swine |
| Chemical | |
Reg. No./Substance:
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0/Ethers; 0/Methyl Ethers; 0/Propionates; 0/Solvents; 105-37-3/ethyl propionate; 1634-04-4/methyl tert-butyl ether; 60-00-4/Edetic Acid; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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