| Toxic effects of acute inhalation exposure to 1,2,4,5-tetramethylbenzene (durene) in experimental animals. | |
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MedLine Citation:
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PMID: 9844309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurotoxic and sensory respiratory irritation effects of 1,2,4,5-tetramethylbenzene (durene) in male rats and male Balb/C mice were investigated in the condition of acute inhalation exposure. Rotarod performance and pain sensitivity behaviour were tested in rats exposed to durene at concentrations of 880, 1100 and 1280 mg/m3 immediately after termination of a four-hour exposure. The respiratory rate was measured in mice by the whole body pletysmographic method in a 6-min exposure to various concentrations of durene. Exposure to durene resulted in concentration-dependent decrease in pain sensitivity in rats and depression of respiratory rate in mice. At applied durene concentrations, no statistically significant disturbances in rotarod performance behaviour were observed. The concentration depressing the respiratory rate to 50% (RD50) was 838 mg/m3. As based on RD50 value, MAC of 25 mg/m3 is suggested for durene. |
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Authors:
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Z Korsak; W Majcherek; K Rydzyński |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of occupational medicine and environmental health Volume: 11 ISSN: 1232-1087 ISO Abbreviation: Int J Occup Med Environ Health Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-13 Completed Date: 1999-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437093 Medline TA: Int J Occup Med Environ Health Country: POLAND |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Affiliation:
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Department of Toxicity and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Animals Benzene Derivatives / administration & dosage, toxicity* Confidence Intervals Disease Models, Animal Dose-Response Relationship, Drug Hypesthesia / chemically induced* Male Maximum Allowable Concentration Mice Mice, Inbred BALB C Pain / physiopathology Rats Rats, Wistar Reaction Time / drug effects Reference Values Respiration / drug effects* Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Benzene Derivatives; 95-93-2/durene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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