Document Detail


Toxic effects of acute inhalation exposure to 1,2,4,5-tetramethylbenzene (durene) in experimental animals.
MedLine Citation:
PMID:  9844309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurotoxic and sensory respiratory irritation effects of 1,2,4,5-tetramethylbenzene (durene) in male rats and male Balb/C mice were investigated in the condition of acute inhalation exposure. Rotarod performance and pain sensitivity behaviour were tested in rats exposed to durene at concentrations of 880, 1100 and 1280 mg/m3 immediately after termination of a four-hour exposure. The respiratory rate was measured in mice by the whole body pletysmographic method in a 6-min exposure to various concentrations of durene. Exposure to durene resulted in concentration-dependent decrease in pain sensitivity in rats and depression of respiratory rate in mice. At applied durene concentrations, no statistically significant disturbances in rotarod performance behaviour were observed. The concentration depressing the respiratory rate to 50% (RD50) was 838 mg/m3. As based on RD50 value, MAC of 25 mg/m3 is suggested for durene.
Authors:
Z Korsak; W Majcherek; K Rydzyński
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of occupational medicine and environmental health     Volume:  11     ISSN:  1232-1087     ISO Abbreviation:  Int J Occup Med Environ Health     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-13     Completed Date:  1999-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437093     Medline TA:  Int J Occup Med Environ Health     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Affiliation:
Department of Toxicity and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Benzene Derivatives / administration & dosage,  toxicity*
Confidence Intervals
Disease Models, Animal
Dose-Response Relationship, Drug
Hypesthesia / chemically induced*
Male
Maximum Allowable Concentration
Mice
Mice, Inbred BALB C
Pain / physiopathology
Rats
Rats, Wistar
Reaction Time / drug effects
Reference Values
Respiration / drug effects*
Survival Rate
Chemical
Reg. No./Substance:
0/Benzene Derivatives; 95-93-2/durene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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