| Toxic effect onset and evaluations of medicinal drugs--horizon for Darwinian toxicological thought. | |
| | |
MedLine Citation:
|
PMID: 20686329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The theory of Darwinian Medicine linked to an extension of Darwin's evolutionary theory is based on the approach from the aspect of "why we become ill?".This theory enables us to understand the relationship between humans and diseases by thinking from evolutional perspective, shows an important help for preventive medicine, and is meaningful to consider the future human healthcare. Toxicology has been defined as a research of adverse effect of xenobiotic substances backed up by diverse-sciences. Toxic effects are basically responses to xenobiotic substances, and expressed as triggering or additional accelerating adverse effects toward abnormal condition. Toxic effects, biological adverse responses, are interpreted as protective responses of living body, and the adverse effects caused by drugs are also considered to be protective responses. This logic can be translated as "Darwinian Toxicology" corresponding to "Darwinian Medicine", replying to "why we get into toxic condition by xenobiotics exposure". This paper refers to the meaning of toxic effects based on mechanisms underlying and comprehensive drug safety evaluation from Darwinian Medicine perspectives. |
| | |
Authors:
|
Ikuo Horii |
Related Documents
:
|
7789109 - Medicine and the lyceum. 20013729 - Practice, theory and authority in a middle english medical text: "barton's urines which... 16699909 - Misnomers in dermatology. 12474849 - Coherence and applied ethics. 11673929 - Spinal manipulative thrust technique using combined movement theory. 22362689 - Genitourinary medicine clinic policies on domestic violence across england and wales: a... 10163009 - How to choose the right capitalization option. 15273159 - The jigcell model builder and run manager. 19823089 - European league against rheumatism/european vasculitis study group recommendations for ... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Journal of toxicological sciences Volume: 35 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-05 Completed Date: 2011-02-09 Revised Date: 2011-07-21 |
Medline Journal Info:
|
Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
|
Languages: eng Pagination: 425-35 Citation Subset: IM |
Affiliation:
|
Showa University, Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Tokyo, Japan. ikuohorii@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Evolution* Drug Toxicity Evolution, Molecular Hominidae Humans Xenobiotics / toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Xenobiotics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Correlation between CVR-R and Carotid Atherosclerosis in Type 2 Diabetes Mellitus Patients with ...
Next Document: Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced r...